Laboratory technology for population-based screening for severe combined immunodeficiency in neonates: The winner is T-cell receptor excision circles
نویسندگان
چکیده
منابع مشابه
Screening for severe combined immunodeficiency in neonates
Severe combined immunodeficiency (SCID) is a rare disease that severely affects the cellular and humoral immune systems. Patients with SCID present with recurrent or severe infections and often with chronic diarrhea and failure to thrive. The disease is uniformly fatal, making early diagnosis essential. Definitive treatment is hematopoietic stem cell transplantation, with best outcomes prior to...
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Severe combined immunodeficiency (SCID) is a life-threatening condition of newborns and infants caused by defects in genes involved in T cell development. Newborn screening (NBS) for SCID using the T cell receptor excision circle (TREC) assay began in Wisconsin in 2008 and has been adopted or is being implemented by all states in 2017. It has been established that NBS using the TREC assay is ex...
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High Throughput Newborn Screening for Severe Combined Immunodeficiency (SCID) Using the Automated T-cell Receptor Excision Circle (TREC) in situ Assay R. Haughton, S. Dever, K. Turner, L. Hancock, J. Taylor, Golriz Yazdanpanah, F. Lee; Virginia Division of Consolidated Laboratory Services, Richmond, VA, Centers for Disease Control and Prevention, Atlanta, GA, RTI International, Research Triangl...
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this thesis is based upon the works of samuel beckett. one of the greatest writers of contemporary literature. here, i have tried to focus on one of the main themes in becketts works: the search for the real "me" or the real self, which is not only a problem to be solved for beckett man but also for each of us. i have tried to show becketts techniques in approaching this unattainable goal, base...
15 صفحه اولDecreased T-cell receptor excision circles in cutaneous T-cell lymphoma.
PURPOSE The T cell repertoire in patients with advanced cutaneous T cell lymphoma (CTCL) is significantly contracted despite the presence of relatively normal absolute numbers of T cells. We propose that many normal T cells were being lost in patients with CTCL, with the remaining normal T cells expanding clonally to fill the T cell compartment. T-cell receptor excision circles (TREC) form as a...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2012
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2012.01.032